Cambridge Healthtech Institute’s Inaugural
Biophysical Methods and Models
New Tools and Strategies for the Biophysical Characterization of Complex Modalities
January 20-21, 2027
Biophysical science is being reshaped by the convergence of computational prediction, automation, and a generation of therapeutic modalities that existing methods were not designed to characterize. The 2027 Cambridge Healthtech Institute's Inaugural Biophysical Methods Conference examines where this convergence is creating genuine analytical capability and where it is still generating more questions than answers.
Coverage will include, but is not limited to:
PREDICTIVE MODELS FOR AGGREGATION, STABILITY, VISCOSITY, AND DEVELOPABILITY
- Combining molecular simulation and machine learning for aggregation and viscosity prediction
- Computational early triage alongside experimental self-interaction and rheology data
- Where models break down: complex formats and non-standard scaffolds
- Building training datasets at scale and predicting the full developability profile
AUTOMATION, DATA INTEGRATION, AND AI-ASSISTED INTERPRETATION
- High-throughput thermal and sizing screens: automation and cascaded workflows
- Automated image analysis for electron microscopy and particle characterization
- Digital twins for analytical methods and data integration challenges
- Regulatory expectations for AI-assisted interpretation and data integrity
- Knowing when to trust AI outputs and when expert review is required
BIOPHYSICAL CHARACTERIZATION OF NOVEL AND COMPLEX MODALITIES
- Multispecific formats: mispairing detection, heterodimer purity, and conformational dynamics
- Charge variant and PTM analytics for complex multi-chain architectures
- ADC higher-order structure: DAR distribution, conjugation-induced changes, and aggregation pathways
- Viral vectors and nanoparticles: AAV empty/full quantitation, LNP architecture, and intact vector characterization
- Bridging biophysical characterization and potency for gene therapy CMC packages
EMERGING HIGHER-ORDER STRUCTURE TOOLS
- Cryo-EM for therapeutic proteins, viral vectors, and lipid nanoparticles
- NMR fingerprinting for biosimilar and process-comparability characterization
- SAXS and SANS for solution-phase structure and molecular interactions
- Native mass spectrometry and ion mobility for intact and complex assemblies
The deadline for priority consideration is June 26, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: